The Essex-born star was known for appearing in a 1985 Levi's advert filmed in a launderette.
His music career peaked the next year with a top five hit Each Time You Break My Heart, co-written by Madonna.
Kamen - real name Ivor Neville Kamen - rose to fame in a jeans commercial, which showed him arrive at a launderette and strip down to his boxer shorts as several women looked on.
The advert, soundtracked by Marvin Gaye's I Heard It Through The Grapevine, helped to boost the company's denim sales and made him a sex symbol in the process.
It also caught the attention of the queen of pop, who told the BBC at the time she had been taken by Kamen's "charisma" and "beautiful voice".
Kamen's follow-up track, a cover of the Four Tops' Loving You Is Sweeter Than Ever, peaked at number 16 in the UK singles chart but reached number one in Italy.
He topped the charts again in Italy with 1988's Tell Me, to which Madonna again provided backing vocals, and got to number one in Austria and Sweden with 1990's I Promised Myself.
Kamen, who was born in Harlow in 1962, is understood to have died on Tuesday night after a long illness.
~ Madonna reacted on her social media:
It breaks my heart to know you are gone. You were always such a kind sweet human and you suffered too much. Hope you are happier wherever you are Nick Kamen.
The Madame X era is not over yet for Madonna. In her latest Insta video she's seen getting a red "X" tattooed on her wrist.
Early December, she got her first tattoo, which was also an initial tattoo: she had the initials of her 6 children tattooed on her other wrist.
↑ Back to top of page